Key result
Graded lower body negative pressure did not alter signal-averaged sympathetic transduction of diastolic blood pressure compared to rest (P=0.43).
Why the study?
Sympathetic transduction of blood pressure correlates negatively with resting muscle sympathetic nerve activity in cross-sectional data, but the acute effects of increasing MSNA remain unclear.
Does graded lower body negative pressure alter sympathetic transduction of blood pressure in young healthy adults?
Comparison
Graded LBNP at -10, -20, and -30 mmHg vs rest
Design
Physiological study
Authors
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Acute MSNA increases via LBNP leave sympathetic transduction unchanged; leaves open mechanisms of resting inverse correlations.
Does graded lower body negative pressure alter sympathetic transduction of blood pressure in young healthy adults?
p-value: p=0.43
Acute increases in muscle sympathetic nerve activity via lower body negative pressure do not alter traditional measures of sympathetic transduction of blood pressure in healthy young adults.
Nardone et al. (2022) studied Healthy adults (n=16). Graded lower body negative pressure (LBNP) vs. Rest was evaluated on Signal-averaged sympathetic transduction of diastolic BP (p=0.43). Graded lower body negative pressure did not alter signal-averaged sympathetic transduction of diastolic blood pressure compared to rest (P=0.43).
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