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November 1, 2002AJP Heart and Circulatory Physiology

Effects of graded LBNP on MSNA and interstitial norepinephrine

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Why the study?

Does graded lower body negative pressure increase muscle sympathetic nerve activity and interstitial norepinephrine in healthy volunteers?

Population

12 healthy volunteers, mean age 26 +/- 6 years

Comparison

Incremental lower body negative pressure paradigm vs Rest (baseline measurements prior to LBNP)

Design

Other

Authors

MKMazhar H. KhanWayne State UniversityLSLawrence I. SinowayGeneral CardiologyDMDavid A. MacLeanUniversity of New Brunswick

Discussion

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Implication

Supports sympathetic indexing in baroreflex research; leaves open translation to disease states or altered clearance mechanisms.

Structured PICO

Does graded lower body negative pressure increase muscle sympathetic nerve activity and interstitial norepinephrine in healthy volunteers?

P
Population
12 healthy volunteers, mean age 26 +/- 6 years
I
Intervention
Incremental lower body negative pressure (LBNP) paradigm (-10, -30, and -50 mmHg)
C
Comparator
Rest (baseline measurements prior to LBNP)
O
Outcome
Relationship between muscle sympathetic nerve activity (MSNA) and interstitial norepinephrine (NE(i)) concentrationssurrogate

Graded lower body negative pressure significantly increases muscle sympathetic nerve activity and interstitial norepinephrine, suggesting decreased norepinephrine clearance into the circulation during baroreceptor unloading.

Cite This Study

Khan et al. (2002) studied this question.

synapsesocial.com/papers/6a73ec97cd7b40c8110dda21https://doi.org/10.1152/ajpheart.00412.2001
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effect of lower body negative pressure on human muscle nerve sympathetic activity1978 · 221 citations
  2. 2Direct neurohumoral evidence for isolated sympathetic nervous system activation to skeletal muscle in response to cardiopulmonary baroreceptor unloading.1990 · 50 citations
  3. 3Low LBNP tolerance in men is associated with attenuated activation of the renin-angiotensin system2000 · 62 citations
  4. 4Simultaneous measurements of cardiac noradrenaline spillover and sympathetic outflow to skeletal muscle in humans.1992 · 299 citations
  5. 5Effects of exercise intensity and duration on norepinephrine spillover and clearance in humans1993 · 73 citations