Key result
Stepwise increases in lower body negative pressure increased renal vascular resistance by 52%, renal norepinephrine overflow by 31%, and renin release by 330%.
Why the study?
Does stepwise lower body negative pressure alter renal hemodynamics and sympathetic nerve activity in healthy volunteers?
Population
10 healthy volunteers
Comparison
Stepwise increases in lower body negative pressure vs Rest (baseline) and low-level LBNP
Design
Other
Authors
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LBNP-induced renal vasoconstriction is sympathetically and angiotensin II-mediated in healthy volunteers; extends mechanistic insights but leaves clinical translation open.
Does stepwise lower body negative pressure alter renal hemodynamics and sympathetic nerve activity in healthy volunteers?
Higher levels of lower body negative pressure cause renal vasoconstriction mediated by increased renal sympathetic nerve activity and angiotensin II.
Tidgren et al. (1990) studied Healthy volunteers (n=10). Lower body negative pressure (LBNP) vs. Rest was evaluated on Renal vascular resistance, renal sympathetic nerve activity, plasma renin activity, and angiotensin II. Stepwise increases in lower body negative pressure increased renal vascular resistance by 52%, renal norepinephrine overflow by 31%, and renin release by 330%.
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