November 2, 2018Clinical Autonomic ResearchOpen Access

Sympathetic activation by lower body negative pressure decreases kidney perfusion without inducing hypoxia in healthy humans

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Why the study?

Does sympathetic activation by lower body negative pressure decrease kidney perfusion and induce hypoxia in healthy humans?

Population

8 healthy volunteers with no significant disease and no medication use.

Comparison

Progressive lower body negative pressure at -15… vs Baseline measurements and recovery to 0 mmHg.

Design

Other

Follow-up

Acute experiment (15 min per LBNP level)

Authors

RBRené van der BelThe Netherlands Cancer Institute JVJasper VerbreeNetherlands Organisation for Applied Scientific Research OGOliver J. Gurney‐ChampionDutch Cancer Society

Discussion

Member takes

Implication

May link sympathetic activation to renal hypoxia in humans; hypothesis-generating for CKD mechanisms, requiring patient validation.

Structured PICO

Does sympathetic activation by lower body negative pressure decrease kidney perfusion and induce hypoxia in healthy humans?

Population

8 healthy volunteers (age 19-31 years, 5 male/3 female, height 1.61-1.85 m, weight 62-76 kg) with no significant disease and no medication use.

Intervention

Progressive lower body negative pressure (LBNP) at -15 and -30 mmHg, 15 min per level.

Comparator

Baseline measurements (before LBNP) and recovery to 0 mmHg.

Outcome

Renal blood flow (RBF) measured by phase-contrast MRI and renal oxygenation (R2*) measured by blood oxygen level dependent (BOLD) MRI.surrogate

Sympathetic activation by lower body negative pressure decreases kidney perfusion but does not induce renal hypoxia in healthy humans, suggesting oxygen demand and supply are suppressed equally.

Limitations

Small sample size
Acute experiment in young healthy subjects versus a chronic pathophysiological process observed in patients
Lack of a comparison between males and females
Absence of direct verification of an increased sympathetic tone
Cannot rule out that other factors (e.g., RAS activation) were superimposed on the sympathetic neural activation

Cite This Study

Bel et al. (2018) studied this question.

synapsesocial.com/papers/6a73b0a2c0a696a45e1af7aa https://doi.org/10.1007/s10286-018-0570-7

View Full Paper

Ask AI

Bookmark

Sympathetic activation by lower body negative pressure decreases kidney perfusion without inducing hypoxia in healthy humans

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Sympathetic activation by lower body negative pressure decreases kidney perfusion without inducing hypoxia in healthy humans

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Also Consider

Also Consider