October 1, 1990AJP Heart and Circulatory Physiology
Sympathetic activity during graded central hypovolemia in hypoxemic humans
Why the study?
Does hypoxemia alter muscle sympathetic nerve activity and vasoconstriction during mild central hypovolemia in men?
Population
8 men
Comparison
Continuous graded lower body negative pressure… vs Continuous graded lower body negative pressure…
Design
Other
Authors
Discussion
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Member takes
Implication
Hypoxemia augments sympathetic responses to mild hypovolemia in healthy men without major defects; leaves open translation to clinical hypoxemic states.
Structured PICO
Does hypoxemia alter muscle sympathetic nerve activity and vasoconstriction during mild central hypovolemia in men?
P
Population
8 men
I
Intervention
Continuous graded lower body negative pressure (LBNP) (-5, -10, -15, -20, and -25 mmHg, 5 min per level) during hypoxemia (10 or 12% O2)
C
Comparator
Continuous graded lower body negative pressure (LBNP) during normoxia
O
Outcome
Muscle sympathetic nerve activity (MSNA)surrogate
Hypoxemia augments muscle sympathetic nerve activity during mild central hypovolemia without major defects in sympathetic control, provided epinephrine levels do not rise.
Cite This Study
Rowell et al. (1990) studied this question.