Key result
Larger resting muscle sympathetic nerve activity bursts were associated with a faster time-to-peak mean arterial pressure response (5.7 seconds for the largest quartile vs 10.1 seconds for the smallest quartile, P<0.01).
Why the study?
The study evaluated the influence of resting muscle sympathetic nerve activity burst size and firing pattern on time-to-peak sympathetic transduction.
Does muscle sympathetic burst size and firing pattern influence time-to-peak sympathetic transduction in young healthy individuals?
Population
36 young healthy men and women
Comparison
MSNA burst size quartiles and burst patterns (singlets/doublets vs triplets/quadruplets)
Design
Physiological study
Authors
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Hypothesis-generating for sympathetic burst size in BP regulation; prospective studies needed before clinical relevance.
Cross-Sectional (n=36)
Yes
Does muscle sympathetic burst size and firing pattern influence time-to-peak sympathetic transduction in young healthy individuals?
Absolute Event Rate: 5.7% vs 10.1%
p-value: p=<0.01
Larger resting muscle sympathetic nerve activity bursts are associated with faster time-to-peak sympathetic transduction (blood pressure response) in young healthy humans, independent of the firing pattern.
Nardone et al. (2021) conducted a cross-sectional in Healthy (n=36). Muscle sympathetic nerve activity (MSNA) burst size vs. Smaller MSNA bursts (Quartiles 1 and 2) was evaluated on Time-to-peak mean arterial pressure (MAP) response (p=<0.01). Larger resting muscle sympathetic nerve activity bursts were associated with a faster time-to-peak mean arterial pressure response (5.7 seconds for the largest quartile vs 10.1 seconds for the smallest quartile, P<0.01).