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January 5, 2013AJP Heart and Circulatory PhysiologyOpen Access

Spontaneous bursts of muscle sympathetic nerve activity decrease leg vascular conductance in resting humans

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Why the study?

Do spontaneous bursts of muscle sympathetic nerve activity decrease leg vascular conductance in resting young men?

Population

11 young men

Comparison

Spontaneous muscle sympathetic nerve activity… vs Cardiac cycles without MSNA bursts

Design

Other

Follow-up

20 min

Authors

SFSeth T. FairfaxGilead Sciences (United States)JPJaume PadillaVascular MedicineLVLauro C. ViannaPreventive Cardiology

Discussion

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Overview

Supports beat-by-beat sympathetic vasoconstriction at rest; hypothesis-generating and leaves open extension to older or clinical populations.

Structured PICO

Do spontaneous bursts of muscle sympathetic nerve activity decrease leg vascular conductance in resting young men?

P
Population
11 young men
I
Intervention
Spontaneous muscle sympathetic nerve activity (MSNA) bursts
C
Comparator
Cardiac cycles without MSNA bursts
O
Outcome
Percent changes in leg vascular conductance (LVC) for 15 cardiac cycles following heartbeatssurrogate

Spontaneous bursts of muscle sympathetic nerve activity dynamically decrease leg vascular conductance on a beat-by-beat basis in resting humans.

Cite This Study

Fairfax et al. (2013) studied this question.

synapsesocial.com/papers/6a204d0e284a522d2e2ed693https://doi.org/10.1152/ajpheart.00842.2012
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Also Consider

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  4. 4Effects of graded LBNP on MSNA and interstitial norepinephrine2002 · 48 citations
  5. 5Augmented Cardiopulmonary and Integrative Sympathetic Baroreflexes but Attenuated Peripheral Vasoconstriction With Age1998 · 203 citations