Why the study?
Does local α-adrenergic blockade attenuate the decrease in forearm vascular conductance following spontaneous MSNA bursts in young healthy men?
Population
19 young healthy men during supine rest
Comparison
Intra-arterial infusions of phentolamine and… vs Intra-arterial infusion of normal saline
Design
Other
Authors
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α-adrenergic mediation of MSNA vasoconstriction confirmed in healthy men; leaves open relevance to patients with cardiovascular disease.
Does local α-adrenergic blockade attenuate the decrease in forearm vascular conductance following spontaneous MSNA bursts in young healthy men?
Spontaneous muscle sympathetic nerve activity bursts evoke robust beat-by-beat decreases in forearm vascular conductance that are exclusively mediated via α-adrenergic receptors.
Fairfax et al. (2013) studied this question.
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