Antihypertensive drug use without a healthy lifestyle was associated with a higher risk of heart failure than a healthy lifestyle without drugs in hypertensive patients (HR 1.75; 95% CI 1.39-2.21).
Cohort (n=38,075)
Does engaging in a healthy lifestyle reduce the risk of heart failure compared to antihypertensive drug treatment alone in adults?
Engaging in a healthy lifestyle is associated with a lower risk of incident heart failure among hypertensive patients, emphasizing the critical role of lifestyle modifications beyond pharmacological therapy.
Hazard Ratio: 1.75 (95% CI 1.39–2.21)
OBJECTIVE: To compare the association between antihypertensive drug treatment and heart failure (HF) risk with the association between engaging in a healthy lifestyle and HF risk. METHODS: We prospectively investigated the single and joint associations of lifestyle factors and awareness, treatment, blood pressure control status with HF risk among 38 075 Finns, who were 25-74 years old and free of HF at baseline. RESULTS: During a median follow-up of 14.1 years, 638 men and 445 women developed HF. Engaging in a healthy lifestyle was associated with an decreased risk of HF. Compared with normotensive people, hypertensive patients with and without antihypertensive treatment had a higher risk of HF. Hypertensive patients who used antihypertensive drugs but did not engage in a healthy lifestyle had a significantly higher risk of HF HR 1.75; 95% confidence interval (CI) 1.39-2.21 than hypertensive patients who did not use antihypertensive drugs but engaged in a healthy lifestyle. In addition, compared with hypertensive patients who used antihypertensive drugs and engaged in a healthy lifestyle, hypertensive patients who did not use antihypertensive drug or engage in a healthy lifestyle had a significantly higher risk of HF (HR 1.55; 95% CI 1.24-1.95). CONCLUSION: The present study demonstrates that HF risk was lower in hypertensive patients who engaged in a healthy lifestyle but higher in hypertensive people using antihypertensive drug treatment.
Wang et al. (Thu,) conducted a cohort in Hypertension and Heart Failure Risk (n=38,075). Antihypertensive drug treatment without a healthy lifestyle vs. Healthy lifestyle without antihypertensive drug treatment was evaluated on Heart failure (HR 1.75, 95% CI 1.39-2.21). Antihypertensive drug use without a healthy lifestyle was associated with a higher risk of heart failure than a healthy lifestyle without drugs in hypertensive patients (HR 1.75; 95% CI 1.39-2.21).
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