Baseline cardiac autonomic neuropathy was strongly associated with early GFR loss (OR 4.09; 95% CI 1.65-10.12; P=0.002) in patients with type 1 diabetes.
Cohort (n=370)
Does baseline cardiac autonomic neuropathy predict early progressive renal decline in patients with type 1 diabetes?
Cardiac autonomic neuropathy is a strong independent predictor of long-term risk for early progressive renal decline in patients with type 1 diabetes.
Odds Ratio: 4.09 (95% CI 1.65–10.12)
Absolute Event Rate: 32% vs 10%
p-value: p=0.002
BACKGROUND AND OBJECTIVES: Cardiac autonomic neuropathy predicts future adverse renal outcomes in the general population. This study sought to determine its relationship with early progressive renal decline in type 1 diabetes. DESIGN, SETTING, PARTICIPANTS, 95% confidence interval, 1.65 to 10.12; P=0.002). Incident advanced CKD was observed in 22 (47%) of those with baseline autonomic neuropathy and 46 (14%) of those without baseline autonomic neuropathy (P<0.001). Autonomic neuropathy was independently associated with incident advanced CKD (adjusted hazard ratio, 2.76; 95% confidence interval, 1.44 to 5.30; P=0.002). CONCLUSIONS: Cardiac autonomic neuropathy was a strong independent predictor of the long-term risk of early progressive renal decline in type 1 diabetes. Future research should explore the mechanisms by which autonomic neuropathy may be associated with renal function loss.
Orlov et al. (Sat,) conducted a cohort in Type 1 diabetes (n=370). Cardiac autonomic neuropathy vs. No baseline cardiac autonomic neuropathy was evaluated on Early GFR loss (slope of eGFR estimated by cystatin C <-3.3%/year) (OR 4.09, 95% CI 1.65-10.12, p=0.002). Baseline cardiac autonomic neuropathy was strongly associated with early GFR loss (OR 4.09; 95% CI 1.65-10.12; P=0.002) in patients with type 1 diabetes.
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