Evaluation of Left Ventricular Function in Cardiomyopathic Mice by Tissue Doppler and Color M‐Mode Doppler Echocardiography

Q: What is the clinical evidence from this study?

Study design: Other. Population: Cardiomyopathy and heart failure (murine models). Intervention: Tissue Doppler imaging and color M-mode Doppler echocardiography vs. Normal controls (NTG). Primary outcome: Left ventricular function assessed by flow propagation velocity (Vp) and early diastolic mitral annulus velocity.

Key Result

Color M-mode Doppler echocardiography can assess LV function in mice, showing greater Vp increases in conscious normal mice compared to cardiomyopathic models, though anesthesia depresses Vp.

Structured PICO

Can Tissue Doppler imaging and color M-mode Doppler echocardiography be used to accurately assess left ventricular function in murine cardiomyopathic models?

Population

Mice exhibiting severe dilated cardiomyopathy, pressure-overload hypertrophy, and normal controls.

Exposure

Tissue Doppler imaging (TDI) and color M-mode Doppler flow propagation velocity (Vp) echocardiography in anesthetized and conscious states

Comparator

Normal controls (NTG) and comparison between anesthetized and conscious states

Outcome

Left ventricular (LV) function parameters including transmitral flow pattern, early diastolic mitral annulus velocity, and propagation velocity (Vp)surrogate

Color M-mode Doppler echocardiography is a feasible tool for assessing LV function in mice, though anesthesia significantly depresses propagation velocity and must be accounted for.

Limitations

Vp is depressed by anesthesia, a complication that can lead to misinterpretation of LV function in normal hearts.

Abstract

Tissue Doppler imaging (TDI) and color M-mode Doppler flow propagation velocity (Vp) are used to assess cardiac function in humans, but the feasibility and applicability of these measurements to murine cardiomyopathic models of heart failure remain unclear. Left ventricular (LV) function was measured by TDI and Vp among mice exhibiting severe dilated cardiomyopathy (TOT), pressure-overload hypertrophy (TAC), and normal controls (NTG). Transmitral flow pattern in TACs and TOTs showed a restrictive filling pattern, but early diastolic mitral annulus velocity was comparable among the three studied groups. Propagation velocity in an anesthetized state was comparable in all three groups. However, while Vp increased in all three groups in the conscious state, the increase in NTGs was statistically greater than in TACs and TOTs. Collectively, results indicate that color M-mode Doppler echocardiography can be used to assess LV function in mice. Furthermore, Vp is depressed by anesthesia, a complication that can lead to misinterpretation of LV function in normal hearts.

Demander à l'IA

Bookmark

Demander à l'IA

Bookmark

Cite This Study

Tsujita et al. (Tue,) conducted a other in Cardiomyopathy and heart failure (murine models). Tissue Doppler imaging and color M-mode Doppler echocardiography vs. Normal controls (NTG) was evaluated on Left ventricular function assessed by flow propagation velocity (Vp) and early diastolic mitral annulus velocity. Color M-mode Doppler echocardiography can assess LV function in mice, showing greater Vp increases in conscious normal mice compared to cardiomyopathic models, though anesthesia depresses Vp.

synapsesocial.com/papers/6a334987f992006f395e79cc https://doi.org/https://doi.org/10.1111/j.0742-2822.2005.04014.x

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: