Key result
Color M-mode Doppler echocardiography can assess LV function in mice, showing greater Vp increases in conscious normal mice compared to cardiomyopathic models, though anesthesia depresses Vp.
Why the study?
Can Tissue Doppler imaging and color M-mode Doppler echocardiography be used to accurately assess left ventricular function in murine cardiomyopathic models?
Population
Murine models including mice exhibiting severe dilated cardiomyopathy, pressure-overload hypertrophy, and…
Comparison
Tissue Doppler imaging and color M-mode Doppler… vs Normal controls and comparison between…
Design
Preclinical
Authors
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Supports color M-mode Doppler for conscious murine LV assessment; hypothesis-generating for clinical use, with anesthesia effects requiring validation.
Can Tissue Doppler imaging and color M-mode Doppler echocardiography be used to accurately assess left ventricular function in murine cardiomyopathic models?
Color M-mode Doppler echocardiography is a feasible tool for assessing LV function in mice, though anesthesia significantly depresses propagation velocity and must be accounted for.
Tsujita et al. (2005) studied Cardiomyopathy and heart failure (murine models). Tissue Doppler imaging and color M-mode Doppler echocardiography vs. Normal controls (NTG) was evaluated on Left ventricular function assessed by flow propagation velocity (Vp) and early diastolic mitral annulus velocity. Color M-mode Doppler echocardiography can assess LV function in mice, showing greater Vp increases in conscious normal mice compared to cardiomyopathic models, though anesthesia depresses Vp.
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