Why the study?
Does flow propagation velocity measured by color M-mode Doppler accurately assess left ventricular diastolic function compared to conventional Doppler parameters?
Does flow propagation velocity measured by color M-mode Doppler accurately assess left ventricular diastolic function compared to conventional Doppler parameters?
Flow propagation velocity measured by color M-mode Doppler is a sensitive and accurate noninvasive parameter for detecting left ventricular diastolic impairment that avoids the pitfall of pseudo-normalization.
FPV may aid noninvasive diastolic assessment where transmitral flow pseudo-normalizes; leaves open prospective validation against Tau before clinical adoption.
Transmitral flow velocity pattern obtained by pulsed Doppler technique reflects left ventricular (LV)diastolic function, but an increase in left atrial pressure pseudo-normalizes the flow pattern and masks diastolic dysfunction. Flow propagation velocity (FPV) measured, using color M-mode Doppler and baseline-shift technique, represents an average velocity of early diastolic LV filling flow from mitral orifice to mid-ventricle. In patients with ischemic heart disease and dilated cardiomyopathy, including those with pseudonormalized transmitral flow pattern, FPV had good correlation with the time constant of early diastolic LV pressure decay (Tau), indicating that FPV is a useful noninvasive diastolic-function parameter which does not pseudo-normalize. Unlike the conventional Doppler parameters, FPV was well correlated with Tau in patients with hypertrophic cardiomyopathy, and was distinctly decreased even in hypertensive patents without LV hypertrophy. Thus, FPV is a unique noninvasive diastolic parameter, which can sensitively and accurately detect LV diastolic impairment.
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Kitabatake et al. (2001) studied this question.
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