Key result
Vp correlates curvilinearly with invasive LV relaxation measures during rapid AF in dogs.
Why the study?
The usefulness of early diastolic mitral flow propagation velocity (Vp) for non-invasive assessment of left ventricular relaxation during atrial fibrillation was unclear.
Does early diastolic mitral flow propagation velocity (Vp) accurately assess left-ventricular relaxation during atrial fibrillation compared to invasive measurements in a canine model?
Does early diastolic mitral flow propagation velocity (Vp) accurately assess left-ventricular relaxation during atrial fibrillation compared to invasive measurements in a canine model?
Non-invasively obtained mitral flow propagation velocity (Vp) can evaluate LV relaxation during atrial fibrillation regardless of ventricular rhythm or pathological changes.
Vp may aid non-invasive LV relaxation assessment in AF; leaves open human translation and clinical utility.
AIMS: To elucidate the usefulness of the early diastolic mitral flow propagation velocity (V(p)) obtained from colour M-mode Doppler for non-invasively assessing left-ventricular (LV) relaxation during atrial fibrillation (AF). METHODS AND RESULTS: Ten healthy adult dogs were studied to correlate V(p) with the invasive minimum value of the first derivative of LV pressure decay (dP/dt(min)) and the time constant of isovolumic LV pressure decay (tau) at baseline, during rapid and slow AF, and during AF after inducing myocardial infarction. There were significant positive and negative curvilinear relationships between V(p) and dP/dt(min) and tau, respectively, during rapid AF. After slowing the ventricular rate, the average value of V(p) increased, while dP/dt(min) increased and tau decreased. After inducing myocardial infarction, the average value of V(p) decreased, while dP/dt(min) decreased and tau increased. CONCLUSION: The non-invasively obtained V(p) evaluates LV relaxation even during AF regardless of ventricular rhythm or the presence of pathological changes.
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Asada-Kamiguchi et al. (2009) studied Atrial fibrillation (n=10). Early diastolic mitral flow propagation velocity (V(p)) vs. Invasive measures (dP/dt(min) and tau) was evaluated on Correlation between V(p) and invasive measures of LV relaxation (dP/dt(min) and tau). Early diastolic mitral flow propagation velocity (V(p)) showed significant curvilinear relationships with invasive measures of left ventricular relaxation during rapid atrial fibrillation in dogs.
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