What is the clinical evidence from this study?

Study design: Observational. Population: Healthy adults (no prior cardiac disease) (n=172). Intervention: Male sex vs. Female sex. Primary outcome: Left ventricular mass index (LV MI) (p=<0.001).

January 1, 2017Open Access

Left Ventricular Functional Parameters and Geometric Patterns in Korean Adults on Coronary CT Angiography with a 320-Detector-Row CT Scanner

Q: What are the key findings of this study?

Male sex was associated with a significantly greater left ventricular mass index compared to female sex (79.6 vs. 66.2 g/m2, p < 0.001) in Korean adults without prior cardiac disease.

Key Result

Male sex was associated with a significantly greater left ventricular mass index compared to female sex (79.6 vs. 66.2 g/m2, p < 0.001) in Korean adults without prior cardiac disease.

Study Design

Type

Observational (n=172)

Multicenter

Structured PICO

Population

172 Korean adults (mean age 58 years, 37.8% female) without prior cardiac disease who underwent coronary CT angiography to establish normal reference values.

Exposure

Coronary CT angiography (CCTA) with a 320-detector-row CT scanner

Outcome

Normal reference values of left ventricle (LV) functional parameters (LV volume, ejection fraction, stroke volume, cardiac output, LV myocardial mass, LV inner diameter, and LV myocardial thickness)surrogate

This study establishes sex-related normal reference values and percentiles for left ventricular functional parameters using 320-detector-row coronary CT angiography in Korean adults.

Main Result

Absolute Event Rate: 79.6% vs 66.2%

p-value: p=<0.001

Limitations

Relatively small number of subjects
Retrospective study design based on medical charts
Inclusion of subjects with co-morbidities such as hypertension, diabetes, and hyperlipidemia
Selective administration of beta-adrenergic receptor blockers for heart rates over 65 bpm, which may influence functional LV parameters
Lack of prior echocardiography in most subjects to definitively confirm cardiac valvular status

Abstract

OBJECTIVE: To assess the normal reference values of left ventricle (LV) functional parameters in Korean adults on coronary CT angiography (CCTA) with a 320-detector-row CT scanner, and to analyze sex-related differences and correlations with various clinical characteristics. MATERIALS AND METHODS: ) who underwent CCTA without any prior history of cardiac disease. The following parameters were measured by post-processing the CT data: LV volume, LV functional parameters (ejection fraction, stroke volume, cardiac output, etc.), LV myocardial mass, LV inner diameter, and LV myocardial thickness (including septal wall thickness SWT, posterior wall thickness PWT, and relative wall thickness RWT = 2 × PWT / LV inner diameter). All of the functional or volumetric parameters were normalized using the BSA. The general characteristics and co-morbidities for the enrolled subjects were recorded, and the correlations between these factors and the LV parameters were then evaluated. RESULTS: = 0.079). Most of the LV parameters were positively correlated with BSA, body weight, and total Agatston score. CONCLUSION: This study provides sex-related reference values and percentiles for LV on cardiac CT and should assist in interpreting results.

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