Fasting insulin was the most significant predictor of left ventricular mass in hypertensives off medication (p=0.0217), whereas BMI and diastolic BP were the significant predictors in controls.
Case-Control
Is fasting insulin associated with echocardiographic left ventricular mass in hypertensives off medication and normotensive controls?
Fasting insulin is a significant predictor of left ventricular mass in hypertensive patients independent of obesity, suggesting a potential mechanism linking insulin resistance to cardiac structural changes.
p-value: p=0.0217
The mechanism by which increased left ventricular (LV) mass leads to increased coronary heart disease morbidity and mortality is unknown. We evaluated the relation between fasting insulin and echocardiographic LV mass in hypertensives off medication and normotensive controls, controlling the analyses for blood pressure (BP) and body mass index (BMI). Fasting insulin (p = 0.0217) was the most significant predictor of LV mass in hypertensives, while BMI (p = 0.0265) and diastolic BP (p = 0.0159) were the only significant predictors of LV mass in controls. The relation between fasting insulin and LV mass was not confounded by obesity in hypertensives, but obesity and fasting insulin may interact to predict LV mass.
Sharp et al. (Fri,) conducted a case-control in Hypertension. Fasting insulin was evaluated on Echocardiographic left ventricular mass (p=0.0217). Fasting insulin was the most significant predictor of left ventricular mass in hypertensives off medication (p=0.0217), whereas BMI and diastolic BP were the significant predictors in controls.