Key result
Fasting insulin was the most significant predictor of left ventricular mass in hypertensives off medication (p=0.0217), whereas BMI and diastolic BP were the significant predictors in controls.
Why the study?
Is fasting insulin associated with echocardiographic left ventricular mass in hypertensives off medication and normotensive controls?
Population
Hypertensives off medication and normotensive controls
Design
Cross-sectional
Authors
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Insulin independently predicts LV mass in hypertensives; leaves open causal role and need for prospective trials.
Case-Control
Is fasting insulin associated with echocardiographic left ventricular mass in hypertensives off medication and normotensive controls?
p-value: p=0.0217
Fasting insulin is a significant predictor of left ventricular mass in hypertensive patients independent of obesity, suggesting a potential mechanism linking insulin resistance to cardiac structural changes.
Sharp et al. (2008) conducted a case-control in Hypertension. Fasting insulin was evaluated on Echocardiographic left ventricular mass (p=0.0217). Fasting insulin was the most significant predictor of left ventricular mass in hypertensives off medication (p=0.0217), whereas BMI and diastolic BP were the significant predictors in controls.
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