Key result
A positive family history of hypertension in untreated hypertensives was associated with reduced insulin sensitivity and significantly lower indices of left ventricular diastolic function.
Why the study?
Does genetic predisposition to hypertension affect insulin sensitivity and left ventricular mass and function in untreated lean and obese hypertensives?
Cross-Sectional (n=197)
Does genetic predisposition to hypertension affect insulin sensitivity and left ventricular mass and function in untreated lean and obese hypertensives?
Genetic predisposition to hypertension is associated with reduced insulin sensitivity and a greater impairment of left ventricular diastolic function in response to increased insulin levels.
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Hypothesis-generating for genetic links to cardiometabolic and diastolic changes; leaves open whether family history alters management in untreated hypertension.
Grandi et al. (1999) conducted a cross-sectional in Untreated hypertension (n=197). Positive family history of hypertension vs. Negative family history of hypertension was evaluated on Insulin sensitivity, left ventricular mass, and left ventricular function. A positive family history of hypertension in untreated hypertensives was associated with reduced insulin sensitivity and significantly lower indices of left ventricular diastolic function.
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