Key result
Insulin sensitivity was inversely related to unadjusted left ventricular mass (r = -0.37, P<0.01), but this relationship disappeared after adjusting for body mass index.
Why the study?
Is insulin sensitivity independently related to left ventricular mass in previously untreated non-diabetic hypertensive patients?
Cross-Sectional (n=51)
Is insulin sensitivity independently related to left ventricular mass in previously untreated non-diabetic hypertensive patients?
Effect estimate: r = -0.37
p-value: p=<0.01
Insulin sensitivity is not independently related to left ventricular mass when adjusting for body size in untreated hypertensive patients, challenging the hypothesis of a direct growth-promoting effect of insulin on the myocardium.
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No independent insulin sensitivity-LVM link after BMI adjustment in untreated hypertension; leaves open body size mediation and direct effects.
Malmqvist et al. (2001) conducted a cross-sectional in Primary hypertension (n=51). Insulin sensitivity was evaluated on Relationship between left ventricular mass and insulin sensitivity index (r = -0.37, p=<0.01). Insulin sensitivity was inversely related to unadjusted left ventricular mass (r = -0.37, P<0.01), but this relationship disappeared after adjusting for body mass index.
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