August 2, 2025
Table S11 from RGN6024 Is a Brain-Penetrant, Small-Molecule Tubulin Destabilizer for the Treatment of Glioblastoma
Key Points
- MAIN FINDING: RGN6024 effectively destabilizes tubulin, showing promise for glioblastoma treatment.
- KEY EVIDENCE: Pharmacokinetic analysis indicates significant brain penetration and favorable plasma levels of RGN6024.
- APPROACH: The study conducted animal trials with rats to evaluate pharmacokinetic parameters.
- SIGNIFICANCE: This research highlights a potential new strategy in targeting glioblastoma through brain-penetrant small molecules.
Abstract
Plasma and brain pharmacokinetic parameters for RGN6024 in rats
Patrón et al. (Fri,) studied this question.
Table S7 from RGN6024 Is a Brain-Penetrant, Small-Molecule Tubulin Destabilizer for the Treatment of Glioblastoma
2025