Figure S19 from B7-H3 CAR T Cells Are Effective against Ependymomas but Limited by Tumor Size and Immune Response

Key Points

• Successful infiltration of HER2.CAR T-cells was observed in ependymoma tumors, but efficacy is constrained.
• Infiltration was successful in 1425 EPN xenograft tumors, highlighting potential for CAR T-cell therapy.
• Tumor size and immune response emerged as critical factors impacting the effectiveness of CAR T cells.
• Challenges arise due to the size of tumors and the inflammatory response, suggesting areas for future research.