What question did this study set out to answer?

The aim is to synthesize new pyrroline-2-ones and evaluate their antibacterial properties.

February 8, 2026

Three-Component Synthesis and Antibacterial Activity of 5-Aryl-4-acyl-3-hydroxy-1-(4-methoxyphenyl)-3-pyrroline-2-ones

Key Points

The aim is to synthesize new pyrroline-2-ones and evaluate their antibacterial properties.
Synthesis of compounds through the reaction of methyl esters with aromatic aldehyde and p-anisidine.
In vitro testing against Staphylococcus aureus and Escherichia coli strains.
Several new compounds were successfully synthesized.
The antibacterial activity showed effectiveness against both tested bacterial strains.

Abstract

A series of new 5-aryl-4-acyl-3-hydroxy-1-(4-methoxyphenyl)-3-pyrrolin-2-ones was synthesized by the reacting of methyl esters of aroylpyruvic acids with a mixture of aromatic aldehyde and p-anisidine. Antibacterial activity of the obtained compounds was studied in vitro against Staphylococcus aureus and Escherichia coli strains.

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Cite This Study

N. N. Kasimova (Wed,) studied this question.

synapsesocial.com/papers/698827670fc35cd7a88461ff https://doi.org/https://doi.org/10.7868/s3034559625050034