What does this research mean for the field?

Patients with left ventricular hypertrophy and heart failure have a 65% reduction in net ATP flux through creatine kinase compared to normal subjects, demonstrating that impaired ATP turnover kinetics distinguish failing from nonfailing hypertrophic hearts. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

This research aims to investigate the energy supply dynamics in heart conditions like left ventricular hypertrophy (LVH) and chronic heart failure (CHF).

September 5, 2006CirculationOpen Access

Patients with left ventricular hypertrophy and heart failure had a 65% reduction in net ATP flux through creatine kinase compared to normal subjects (1.1 vs 3.1 µmol/g/s, P<0.001).

Q: What is the clinical evidence from this study?

Study design: Observational. Population: Left ventricular hypertrophy and chronic heart failure (n=34). Intervention: Left ventricular hypertrophy with chronic heart failure vs. Normal subjects and nonfailing left ventricular hypertrophy. Primary outcome: Net ATP flux through creatine kinase (p=<0.001).

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Population

34 subjects including patients with left ventricular hypertrophy, patients with LVH and chronic heart…

Design

Cross-sectional

Key result

Patients with left ventricular hypertrophy and heart failure had a 65% reduction in net ATP flux through creatine kinase compared to normal subjects (1.1 vs 3.1 µmol/g/s, P<0.001).

Authors

CSCraig S. Smith PBPaul A. Bottomley SSSteven P. Schulman

Discussion

Member takes

Overview

Reduced CK flux in failing vs nonfailing LVH supports energy deficit hypothesis; hypothesis-generating and should not yet change practice.

Key Points

This research aims to investigate the energy supply dynamics in heart conditions like left ventricular hypertrophy (LVH) and chronic heart failure (CHF).
Measured myocardial creatine kinase metabolite concentrations and ATP synthesis
Compared data between LVH patients (n=10), LVH+CHF patients (n=10), and normal subjects (n=14)
Assessed relations between creatine phosphate levels and CK rate constants
Creatine phosphate levels were 35% lower in LVH patients than normal subjects (P < 0.006)
ATP flux decreased by 30% in LVH patients and 65% in LVH+CHF patients compared to normal subjects (P < 0.001)
Myocardial CK rate constant halved in LVH+CHF compared to normal (0.17 ± 0.06 s(-1) vs. 0.32 ± 0.06 s(-1), P < 0.001)

Study Design

Type

Observational (n=34)

Structured PICO

Population

34 subjects including patients with left ventricular hypertrophy (LVH, n=10), patients with LVH and chronic heart failure (LVH+CHF, n=10), and normal subjects (n=14).

Outcome

Myocardial creatine kinase (CK) metabolite concentrations and adenosine triphosphate (ATP) synthesis through CKsurrogate

Main Result

Absolute Event Rate: 1.1% vs 3.1%

p-value: p=<0.001

The kinetics of ATP turnover through creatine kinase, rather than metabolite pool sizes, distinguish failing from nonfailing hypertrophic human hearts, suggesting a deficit in energy delivery contributes to heart failure pathophysiology.

Cite This Study

Smith et al. (2006) conducted an observational in Left ventricular hypertrophy and chronic heart failure (n=34). Left ventricular hypertrophy with chronic heart failure vs. Normal subjects and nonfailing left ventricular hypertrophy was evaluated on Net ATP flux through creatine kinase (p=<0.001). Patients with left ventricular hypertrophy and heart failure had a 65% reduction in net ATP flux through creatine kinase compared to normal subjects (1.1 vs 3.1 µmol/g/s, P<0.001).

synapsesocial.com/papers/6a15da2d1362a77db8e3c516 https://doi.org/10.1161/circulationaha.106.613646

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September 5, 2006CirculationOpen Access

Patients with left ventricular hypertrophy and heart failure had a 65% reduction in net ATP flux through creatine kinase compared to normal subjects (1.1 vs 3.1 µmol/g/s, P<0.001).

View Full Paper

Ask AI

Bookmark

Population

34 subjects including patients with left ventricular hypertrophy, patients with LVH and chronic heart…

Design

Cross-sectional

Key result

Patients with left ventricular hypertrophy and heart failure had a 65% reduction in net ATP flux through creatine kinase compared to normal subjects (1.1 vs 3.1 µmol/g/s, P<0.001).

Authors

CSCraig S. Smith PBPaul A. Bottomley SSSteven P. Schulman

Discussion

Member takes

Overview

Reduced CK flux in failing vs nonfailing LVH supports energy deficit hypothesis; hypothesis-generating and should not yet change practice.

Key Points

This research aims to investigate the energy supply dynamics in heart conditions like left ventricular hypertrophy (LVH) and chronic heart failure (CHF).
Measured myocardial creatine kinase metabolite concentrations and ATP synthesis
Compared data between LVH patients (n=10), LVH+CHF patients (n=10), and normal subjects (n=14)
Assessed relations between creatine phosphate levels and CK rate constants
Creatine phosphate levels were 35% lower in LVH patients than normal subjects (P < 0.006)
ATP flux decreased by 30% in LVH patients and 65% in LVH+CHF patients compared to normal subjects (P < 0.001)
Myocardial CK rate constant halved in LVH+CHF compared to normal (0.17 ± 0.06 s(-1) vs. 0.32 ± 0.06 s(-1), P < 0.001)

Study Design

Type

Observational (n=34)

Structured PICO

Population

34 subjects including patients with left ventricular hypertrophy (LVH, n=10), patients with LVH and chronic heart failure (LVH+CHF, n=10), and normal subjects (n=14).

Outcome

Myocardial creatine kinase (CK) metabolite concentrations and adenosine triphosphate (ATP) synthesis through CKsurrogate

Main Result

Absolute Event Rate: 1.1% vs 3.1%

p-value: p=<0.001

Cite This Study

synapsesocial.com/papers/6a15da2d1362a77db8e3c516 https://doi.org/10.1161/circulationaha.106.613646

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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