Why the study?
Do changes in the creatine kinase system correlate with the transition to cardiac failure and decreased functional capacity?
Population
Two animal models of hypertrophy with cardiac dysfunction and patients with various forms of cardiomyopathy…
Comparison
Antihypertensive treatment for 6 months in… vs Untreated animals or non-hypoxic conditions.
Design
Preclinical
Follow-up
6 months (for antihypertensive treatment)
Authors
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No immediate implications for heart failure management; leaves open whether creatine kinase modulation could target energy metabolism.
Do changes in the creatine kinase system correlate with the transition to cardiac failure and decreased functional capacity?
Decreased energy reserve for ATP synthesis, marked by reduced creatine kinase activity, correlates with and may causally contribute to systolic and diastolic heart failure.
Ingwall et al. (1990) studied this question.
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