Key result
In a rat model of congestive heart failure, total creatine kinase activity decreased, driven by a 4-fold decrease in mitochondrial CK and a 30% decrease in MM-CK activity.
Population
3-week-old rats with heart failure induced by aortic banding
Comparison
Heart failure induced by aortic banding vs Control rats (implied by comparative decreases)
Design
Preclinical
Follow-up
7 months
Authors
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CK alterations may impair myocardial energetics in HF; leaves open therapeutic targeting pending human studies.
Alterations in creatine kinase compartmentation in the failing myocardium contribute to impaired energy fluxes and calcium homeostasis in congestive heart failure.
Sousa et al. (1999) studied Congestive heart failure. Aortic banding vs. Control was evaluated on Subcellular creatine kinase alterations, energy fluxes, and calcium homeostasis. In a rat model of congestive heart failure, total creatine kinase activity decreased, driven by a 4-fold decrease in mitochondrial CK and a 30% decrease in MM-CK activity.
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