Why the study?
Does myocardial hypertrophy alter the distribution of creatine kinase isozymes in animal models?
Population
Dogs and rats with myocardial hypertrophy produced by volume overload, pressure overload, elevated thyroxine…
Comparison
Induction of myocardial hypertrophy vs Normal/non-hypertrophied hearts (implied)
Design
Preclinical
Authors
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Animal data associate fetal CK isozymes with compensated hypertrophy; leaves open relevance to human HF progression or monitoring.
Does myocardial hypertrophy alter the distribution of creatine kinase isozymes in animal models?
Compensated myocardial hypertrophy is characterized by an accumulation of fetal-type MB-creatine kinase isozymes, whereas the transition to heart failure is marked by a decrease in mitochondrial creatine kinase activity.
J. S. Ingwall (1984) studied this question.
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