Key result
Suprarenal aortic banding increased total creatine kinase activity in the left ventricle compared to sham operation (1,096 vs 648 IU/g, p<0.01) without an isoenzyme switch.
Absolute Event Rate: 1096% vs 648%
p-value: p=<0.01
In a rat model of acute pressure overload, increased energy requirements are met by generalized induction of creatine kinase mRNA and subunit protein rather than an isoenzyme switch.
No takes yet. Share an insight, caveat, or question.
Rat pressure-overload data on creatine kinase induction remain hypothesis-generating; leaves open relevance to human hypertrophy or energetics.
Fontanet et al. (1991) studied Arterial hypertension / pressure overload (n=12). Suprarenal aortic banding (pressure overload) vs. Sham operation was evaluated on Total creatine kinase activity in left ventricle (IU/g) (p=<0.01). Suprarenal aortic banding increased total creatine kinase activity in the left ventricle compared to sham operation (1,096 vs 648 IU/g, p<0.01) without an isoenzyme switch.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: