Why the study?
Does captopril normalize ventricular myosin and creatine-kinase isoenzyme distribution in hypertensive rats?
Does captopril normalize ventricular myosin and creatine-kinase isoenzyme distribution in hypertensive rats?
In a rat model of renovascular hypertension, captopril reverses ventricular hypertrophy and myosin isoenzyme shifts, but does not fully normalize creatine kinase isoenzyme profiles.
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Captopril's partial normalization in this rat model warrants clinical caution; leaves open whether adjunctive targets are needed for full CK isoenzyme restoration.
Pauletto et al. (1989) studied this question.
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