Why the study?
Do serum creatine kinase MM isoforms indicate persistent myocardial release in patients with hypertrophic cardiomyopathy compared to normal controls?
Do serum creatine kinase MM isoforms indicate persistent myocardial release in patients with hypertrophic cardiomyopathy compared to normal controls?
Patients with hypertrophic cardiomyopathy exhibit a persistent release of the myocardial tissue isoform of creatine kinase MM (MMa), suggesting ongoing myocardial tissue turnover or injury.
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May indicate ongoing myocardial turnover in HCM; hypothesis-generating for isoform-based monitoring.
To determine whether a persistent release of creatine kinase from the myocardium occurs in patients with hypertrophic cardiomyopathy, the activities of serum creatine kinase MM isoforms were measured in 22 patients with hypertrophic cardiomyopathy and in 14 normal control subjects. 2. Serum creatine kinase MB activity was significantly higher in patients with hypertrophic cardiomyopathy (7.8 +/- 3.8 i.u./l) than in normal control subjects (0.4 +/- 0.8 i.u./l; P less than 0.01). 3. Serum MMa, MMb and MMc activities in patients with hypertrophic cardiomyopathy were 19.4 +/- 4.1%, 26.7 +/- 2.5% and 33.5 +/- 7.0% of the total creatine kinase MM activity, respectively. These values for each isoform were significantly different from those in normal control subjects (11.3 +/- 3.0%, 21.5 +/- 4.4% and 40.7 +/- 7.0%, respectively). The MMa/MMc activity ratio was significantly higher in patients with hypertrophic cardiomyopathy (0.61 +/- 0.25) than in normal control subjects (0.30 +/- 0.10; P less than 0.01). 4. Our results indicate that a small amount of the myocardial tissue isoform of creatine kinase MM (MMa) is constantly released in many patients with hypertrophic cardiomyopathy.
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Hamada et al. (1991) studied this question.
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