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December 11, 2013Science Translational MedicineOpen Access

For each increase in CK flux of 1 μmol g⁻¹ s⁻¹, risk of HF-related composite outcomes decreased by 32 to 39%.

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Why the study?

Does reduced myocardial CK flux predict HF-related composite outcomes in patients with nonischemic cardiomyopathy?

Population

58 heart failure patients with nonischemic cardiomyopathy

Design

Cohort

Follow-up

median 4.7 years

Authors

PBPaul A. BottomleyGPGurusher PanjrathSLShenghan Lai

Discussion

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Overview

May support CK flux for risk stratification in nonischemic cardiomyopathy; leaves open whether targeting it improves outcomes.

Structured PICO

Does reduced myocardial CK flux predict HF-related composite outcomes in patients with nonischemic cardiomyopathy?

P
Population
58 heart failure patients with nonischemic cardiomyopathy
I
Intervention
Measurement of cardiac high-energy phosphates and the rate of ATP synthesis through creatine kinase (CK flux) using ³¹P magnetic resonance spectroscopy (MRS)
O
Outcome
Composite of HF-related events including all-cause and cardiac death, HF hospitalization, cardiac transplantation, and ventricular-assist device placementcomposite

Reduced myocardial CK flux measured by ³¹P MRS is an independent predictor of adverse clinical outcomes in patients with nonischemic cardiomyopathy.

Cite This Study

Bottomley et al. (2013) studied this question.

synapsesocial.com/papers/6a70bd79660549caf2c55d86https://doi.org/10.1126/scitranslmed.3007328
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