Key result
Creatine kinase flux, but not metabolite levels or PCr/ATP, was an independent predictor of all-cause and cardiovascular mortality in patients with non-ischemic cardiomyopathy.
Why the study?
Does the rate of ATP transfer via creatine kinase predict adverse clinical outcomes in patients with nonischemic cardiomyopathy?
Does the rate of ATP transfer via creatine kinase predict adverse clinical outcomes in patients with nonischemic cardiomyopathy?
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Noninvasive measurement of ATP transfer via creatine kinase by magnetic resonance spectroscopy independently predicts adverse clinical outcomes in nonischemic cardiomyopathy, highlighting the potential of metabolic imaging for risk stratification.
Lygate et al. (2014) conducted an editorial in Non-ischemic cardiomyopathy (n=75). Creatine kinase (CK) flux measured by 31P-MRS vs. Metabolite levels or PCr/ATP ratio was evaluated on All-cause and cardiovascular mortality and/or hospitalization. Creatine kinase flux, but not metabolite levels or PCr/ATP, was an independent predictor of all-cause and cardiovascular mortality in patients with non-ischemic cardiomyopathy.
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