CRUK Lung Cancer Centre of Excellence

Recent papers from CRUK Lung Cancer Centre of Excellence

1. The cancer research UK and UCL Cancer Trials Centre (CTC) patient engagement day 2025 - celebrating patient involvement and engagement in clinical researchResearch Involvement and Engagement · 2026
2. Osimertinib–Savolitinib in Advanced NSCLC after Progression during EGFR-TKI TherapyNew England Journal of Medicine · 2026
3. How could calreticulin-targeting therapies change the myelofibrosis transplant paradigm?Bone Marrow Transplantation · 2026
4. Cerebrospinal fluid and plasma circulating tumor DNA dynamics as a biomarker of response during trastuzumab deruxtecan treatment in patients with breast cancer with leptomeningeal diseaseClinical Cancer Research · 2026
5. Addition of chemotherapy to radiotherapy promotes progenitor-exhausted CD8⁺ T-cell clonal dominance in head and neck cancerCancer Immunology Research · 2026
6. A preinvasive regulatory T cell axis for lung cancer interceptionNature · 2026
7. One cycle of nelarabine given after induction is well tolerated but does not improve outcome in adults with T‐cell precursor acute lymphoblastic leukemia: Outcome data from the UKALL14 randomized‐controlled trialHemaSphere · 2026
8. Rethinking colitis: MrgprD puts macrophages in the driver's seat †The Journal of Pathology · 2026
9. Setanaxib Added to Pembrolizumab for Fibroblast-Rich, Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck: a Phase 2 Randomized StudyCancer Research Communications · 2026
10. γδ T cell receptor dependencies define a unique immunosurveillance modalityNature · 2026
11. Safety and efficacy of ceralasertib, an ATR kinase inhibitor, combined with olaparib: dose escalation in advanced solid tumours and dose expansion in advanced breast cancerBritish Journal of Cancer · 2026
12. Image-based Detection of Mismatch Repair Deficiency in Prostate Cancer Using Transfer LearningClinical Cancer Research · 2026
13. Clinical and Molecular Profiles of Treatment-Emergent Small Cell Neuroendocrine Prostate Cancers in the Era of Intensified Systemic TherapiesCancer Research Communications · 2026
14. A multimodal AI biomarker PATH-ORACLE improves prediction of recurrence in stage I lung adenocarcinomaImmuno-Oncology Technology · 2026
15. Acute Myeloid Leukaemia Driven by Rare HNRNPH1::ERG Fusion Gene in an Adult, With Distinct Transcripts Detected by RNASeq at Diagnosis and Relapse: A Case ReporteJHaem · 2026
16. Amivantamab plus pembrolizumab in previously untreated recurrent/metastatic head and neck squamous cell cancer: Results from the phase 1b/2 OrigAMI-4 studyClinical Cancer Research · 2026
17. Invited submission to Reproduction and Fertility for “Evolving Perspectives in Management of Menopause Transition” SeriesReproduction and Fertility · 2026
18. FasL-mediated death of activated intratumoral T cells drives secondary resistance to cancer immunotherapyCancer Immunology Research · 2026
19. Molecularly Guided Therapy Versus Continued Chemotherapy in Unfavorable Cancer of Unknown Primary: Updated Efficacy and Safety From the Randomized, Phase II CUPISCO StudyJournal of Clinical Oncology · 2026
20. Critical role for the TGF-β1/mTORC1 signaling axis in defining the transcriptional identity of CTHRC1 + pathologic fibroblastsScience Advances · 2026