Helmholtz Institute for Pharmaceutical Research Saarland

Recent papers from Helmholtz Institute for Pharmaceutical Research Saarland

1. Active Learning for Fragment-Based Kinase Inhibitor Discovery using Docking2026
2. Biocatalysts for Peptide Geranylation With Linear and Cyclic Prenyl GroupsAngewandte Chemie International Edition · 2026
3. Characterization of the Gametocytocidal and Putative Transmission-Blocking Activity of Chlorotonil A Against Plasmodium falciparumPharmaceutics · 2026
4. Natural product biosynthesis by guanidine prenyltransferases in plants and bacteriaScience · 2026
5. Continuous UV-Spectroscopic Interrogation of Enzymes Processing Phosphorylated Intermediates through Modular Reaction NetworksAnalytical Chemistry · 2026
6. Validation of Small‐Molecule Entry Inhibitors Targeting the Respiratory Syncytial VirusChemMedChem · 2026
7. The 20 th EFMC Short Course on Medicinal Chemistry Dedicated to Atypical Approaches Focusing on Protein TargetsChemMedChem · 2026
8. Error correction algorithms for efficient gene expression quantification in single cell transcriptomics with ArcaneGenome Research · 2026
9. Safety and pharmacokinetics of inhaled aloxistatin: A first‐in‐human phase 1 dose escalation trialBritish Journal of Clinical Pharmacology · 2026
10. Assessing the state of the art in ADMET prediction: Lessons from the OpenADMET-ExpansionRx community blind challenge2026
11. Biopsy-proven BK polyomavirus nephropathy in a lung transplant recipientKidney International Case Reports · 2026
12. miRNA Isoform Spectrum Expansion by Overexpression May Affect Target Gene SilencingGenomics Proteomics & Bioinformatics · 2026
13. Assessing the state of the art in ADMET prediction: Lessons from the OpenADMET-ExpansionRx community blind challenge2026
14. Generative AI designs functional thiolation domains for reprogramming non-ribosomal peptide synthetasesNature Communications · 2026
15. Assessing the state of the art in ADMET prediction: Lessons from the OpenADMET-ExpansionRx community blind challenge2026
16. Toxicokinetics and analytical toxicology of four N, N-dimethyltryptamine derivatives studied in human in vitro systems and in vivo by means of zebrafish embryosArchives of Toxicology · 2026
17. DockM8: an all-in-one open-source platform for consensus virtual screening in drug designJournal of Cheminformatics · 2026
18. Effect of Poly[oligo(ethylene glycol) methyl ether methacrylate] (POEGMA) Side-Chain Length on the Antimicrobial Activity of Tobramycin-POEGMA Conjugates against Pseudomonas aeruginosaACS Polymers Au · 2026
19. Phenazine Biosynthesis Inhibitors as Pseudomonas aeruginosa Antivirulence AgentsACS Bio & Med Chem Au · 2026
20. “Sex-divergent responses to microglial depletion suggest distinct regulatory dependencies in the aged brain”2026