IRBM Science Park

Recent papers from IRBM Science Park

1. Crystal Structureof the Sigma-2 Receptor Complexedwith Investigational Drug Zervimesine (CT1812)ACS Medicinal Chemistry Letters · 2026
2. Discovery andPreclinical Characterization of I-0436650,a Selective SHP2 Allosteric Inhibitor for RAS-Driven CancersJournal of Medicinal Chemistry · 2026
3. Dimer Persistence, Packing Adaptation, and Structural Choices in Solvated RifaximinCrystal Growth & Design · 2026
4. Design and assessment of plowshares for industrial mixers using DEMPowder Technology · 2026
5. Discovery and Optimization of IRBM-Z-2, an Allosteric Zika Virus NS2B-NS3 Protease Inhibitor Exhibiting In Vivo EfficacyJournal of Medicinal Chemistry · 2026
6. Discovery Process of Enlicitide, a Highly Engineered Macrocyclic Peptide Therapeutic, through Issue-Driven Fragment-Based Synthetic Assembly and SARJournal of Medicinal Chemistry · 2026
7. The RNA binding protein LIN28A mediates chromatin dynamics during neuronal differentiationCell Death and Differentiation · 2026
8. DPY30 is an epigenetic decoupler linking replication stress to immunoediting in pancreatic cancerCancer Research · 2026
9. Plasma metabolomic profiling identifies a metabolic signature for non–muscle-invasive bladder cancer independent of hematuriaBiology Direct · 2026
10. Abstract 681: C3PO: complex 3D patient organoids for preclinical drug testing in brain tumors.Cancer Research · 2026
11. Targeting Colorectal Cancer Stem Cells Through Inhibition of the Fibroblast Growth Factor Receptor 4 Pathway with a Novel AntibodyCancers · 2026
12. An allosteric inhibitor of the Zika virus NS2B-NS3 protease with oral efficacy in mouse modelsNature Communications · 2026
13. In silico screening and preclinical validation identify bavisant as a therapeutic candidate for multiple sclerosis.2026
14. Correlation between active regions’ spectra at high radio frequencies and solar flare occurrencesScientific Reports · 2026
15. Learnt formant modulation via upper vocal tract movements in a marine mammalDiscover Animals · 2026
16. Breast Imaging Findings in Women with Lipedema: A Retrospective Cross-Sectional Descriptive StudyJournal of Clinical Medicine · 2025
17. Post-translational modifications of huntingtin's N17 region: implications for self-association and membrane bindingBiochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · 2025
18. Isoindolinone-Based PET Tracers for Imaging Mutant Huntingtin AggregatesJournal of Medicinal Chemistry · 2025
19. Optimization of Single Relaxin B-Chain Peptide Leads to the Identification of R2R01, a Potent, Long-Acting RXFP1 Agonist for Cardiovascular and Renal DiseasesJournal of Medicinal Chemistry · 2025
20. De novo discovery of cyclic peptide inhibitors of IL-11 signalingBioorganic & Medicinal Chemistry · 2024