Targeting Colorectal Cancer Stem Cells Through Inhibition of the Fibroblast Growth Factor Receptor 4 Pathway with a Novel Antibody

Gessica Filocamo; Mariachiara Buccarelli; Armin Lahm; Mirko Brunetti; Chantal Paolini; Gabriele De Luca; Michele Signore; Giorgia Castellani; Alessandra Boe; Romina Alfonsi; Mauro Biffoni; Ruggero De Maria; Lucia Ricci-Vitiani; Christian Steinkühler; Dante Rotili

doi:10.3390/cancers18030418

January 28, 2026CancersOpen Access

Targeting Colorectal Cancer Stem Cells Through Inhibition of the Fibroblast Growth Factor Receptor 4 Pathway with a Novel Antibody

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Key Points

Successful identification of CSC-selective membrane antigens highlights potential therapeutic targets.
FGFR4 inhibition using the anti-FGFR4 3B6 monoclonal antibody reveals diagnostic and therapeutic promise.
The development of the 3B6 antibody specifically targets colorectal cancer stem cells effectively.
Implications for colorectal cancer therapy emphasize the need for targeting stem cell pathways in treatment strategies.

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Implication

Observational analysis identifies FGFR4 as a target for colorectal cancer stem cells, suggesting new therapeutic strategies.

Abstract

This study successfully identified several CSC-selective membrane antigens that can become therapeutic targets in CRC. Among them, we focused on FGFR4 as a promising target and developed the anti-FGFR4 3B6 monoclonal antibody which offers potential for both diagnostic and therapeutic applications.

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Cite This Study

Filocamo et al. (2026) studied this question.

synapsesocial.com/papers/69a75d0cc6e9836116a26741 https://doi.org/10.3390/cancers18030418

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Targeting Colorectal Cancer Stem Cells Through Inhibition of the Fibroblast Growth Factor Receptor 4 Pathway with a Novel Antibody

Key Points

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Implication

Abstract

Discussion

Cite This Study

Targeting Colorectal Cancer Stem Cells Through Inhibition of the Fibroblast Growth Factor Receptor 4 Pathway with a Novel Antibody

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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