AstraZeneca (Germany)

Recent papers from AstraZeneca (Germany)

1. Normalized membrane ratio of TROP2 as a predictor of clinical outcomes with datopotamab deruxtecan in non-small-cell lung cancerNature Medicine · 2026
2. Selective binders of a cotranslational folding intermediate2026
3. Rapid Alternating Polarity‐Enabled Electrochemical Decarboxylative Borylation of Aryl Carboxylic AcidsChemElectroChem · 2026
4. In Vitro Exploration of Antisense and Splice-Switching Oligonucleotide Multimers Using an Engineered Peptide ScaffoldJournal of Medicinal Chemistry · 2026
5. Chemogenomic maps reveal a PRDX1-dependent iron–damage axis in the DNA damage responseNature Chemical Biology · 2026
6. Beyond natural amino acids: extending immunogenicity risk assessment to modified peptides through chemical feature encoding. A case study on citrullinationFrontiers in Immunology · 2026
7. Single-cell and in vivo profiling reveal heterogeneous and organ-specific CRISPR-Cas9 off-target and translocation outcomesNature Communications · 2026
8. Epithelial–mesenchymal transition in carcinoma: navigating phenotypic states to target resistance and metastasisCancer and Metastasis Reviews · 2026
9. Optimize reliance pathways to advance patient’s access through good regulatory practice: recommendations from the Asia Partnership Conference of Pharmaceutical Associations (APAC)AAPS Open · 2026
10. Isolation of Novel Fully Human Single-Domain Antibodies Targeting GUCY2C from a Heavy-Chain-Only Transgenic Mouse PlatformTechnology in Cancer Research & Treatment · 2026
11. PBPK Modeling of Esomeprazole to Support Adolescent Pharmacokinetic Extrapolation and Label Extension in Chinese Patients With Gastroesophageal Reflux Disease (GERD)The Journal of Clinical Pharmacology · 2026
12. Simultaneous targeting of IL-10 and PD-(L)1 pathways with a bispecific anti-PD-L1/IL-10-trap antibody enhances T cell responsesMolecular Therapy Oncology · 2026
13. Defining Composition–Cytokine Relationships Enables the Design of Lipid Nanoparticles with Programmed ImmunogenicitySmall · 2026
14. Generative AI-Assisted Discovery of HPK1 InhibitorsJournal of Medicinal Chemistry · 2026
15. GOLD-concordant inhaled maintenance therapy at hospital discharge after hospitalisation for severe COPD exacerbation: a multicentre retrospective observational studyThe Lancet Regional Health - Europe · 2026
16. X-ray Crystallography-Guided Design and Synthesis of Cyclopentyl Heteroaryl Carboxylic Acid-Based Inhibitors of the SARS-CoV-2 Nsp3 Macrodomain (Mac1)Journal of Medicinal Chemistry · 2026
17. Structural basis of biofilm formation mediated by the Pseudomonas aeruginosa fibrillar adhesin CdrA2026
18. The ITCC-P4 PDX Platform Enables Preclinical Testing of Pediatric CancersCancer Research · 2026
19. Harnessing the Reactivity of Sulfinate Salts With Cystine: An Umpolung Approach to Residue‐Specific Peptide ModificationAngewandte Chemie International Edition · 2026
20. Harnessing the Reactivity of Sulfinate Salts With Cystine: An Umpolung Approach to Residue‐Specific Peptide ModificationAngewandte Chemie · 2026