Relay Therapeutics (United States)

Recent papers from Relay Therapeutics (United States)

1. Scalable variant-to-function screens using prime editing perturb-seq2026
2. Cryptic small-molecule binding sites in the ARID1B DNA-binding domainProceedings of the National Academy of Sciences · 2026
3. A Computational Community Blind Challenge on Pan-Coronavirus Drug Discovery DataJournal of Chemical Information and Modeling · 2026
4. Abstract PD10-07: Efficacy of mutant-selective PI3Kα inhibitor RLY-2608 in combination with fulvestrant in patient (pt) subset populations, including pts with PIK3CA-mutant HR+/HER2- advanced breast cancer (BC) pre-treated with fulvestrant or other SERDClinical Cancer Research · 2026
5. Large-scale mouse mutagenesis identifies novel genes affecting vertebral anatomyMammalian Genome · 2026
6. CACHE Challenge #3: Targeting the Nsp3 Macrodomain of SARS-CoV-2Journal of Chemical Information and Modeling · 2026
7. Process Development and Scale-Up of RLY-2139: A Selective CDK2 Inhibitor Targeting ER+/HER2– Breast CancerOrganic Process Research & Development · 2026
8. From Chiral Separation to Asymmetric Synthesis: Route Scouting and Early Process Development of a Chiral Tetrahydrofuran–Pyrazolamine Intermediate of CDK2 Inhibitor RLY-2139Organic Process Research & Development · 2026
9. DNA-Encoded Chemical Library Screening with Target Titration Analysis: DELTAJournal of Medicinal Chemistry · 2026
10. Physiologically‐Based Pharmacokinetic Modeling to Support Pediatric Clinical Development: An IQ Working Group Perspective on the Current Status and ChallengesCPT Pharmacometrics & Systems Pharmacology · 2025
11. Physiologically‐Based Pharmacokinetic Modeling to Support Pediatric Clinical Development: An IQ Working Group Perspective on the Current Status and ChallengesCPT Pharmacometrics & Systems Pharmacology · 2025
12. Enhanced Thompson sampling by roulette wheel selection for screening ultralarge combinatorial librariesJournal of Cheminformatics · 2025
13. CACHE Challenge #3: Targeting the Nsp3 Macrodomain of SARS-CoV-22025
14. A Computational Community Blind Challenge on Pan-Coronavirus Drug Discovery Data2025
15. Practically Significant Method Comparison Protocols for Machine Learning in Small Molecule Drug DiscoveryJournal of Chemical Information and Modeling · 2025
16. Nanoscale direct-to-biology optimization of Cdk2 inhibitors2025
17. Macrocycles for Conventionally Druggable Targets: Lessons from Macrocyclic Kinase InhibitorsJournal of Medicinal Chemistry · 2025
18. CACHE Challenge #2: Targeting the RNA Site of the SARS-CoV-2 Helicase Nsp13Journal of Chemical Information and Modeling · 2025
19. Exploration of structure-activity relationships for the SARS-CoV-2 macrodomain from shape-based fragment linking and active learningScience Advances · 2025
20. Machine Learning for Toxicity Prediction Using Chemical Structures: Pillars for Success in the Real WorldChemical Research in Toxicology · 2025