State Key Laboratory of Drug Research

Recent papers from State Key Laboratory of Drug Research

1. Engineered Milk‐Derived Extracellular Vesicles Integrate PCSK9 Silencing and Inflammation Modulation for Hyperlipidemia TherapyAdvanced Healthcare Materials · 2026
2. Serotonin Reuptake Inhibition Reduces NMDAR-Associated Reward Liability Without Compromising Rapid Antidepressant Efficacy2026
3. Preliminary Evaluation of the Anticancer Activity of a PGK1 Small Molecule Inhibitor in Ishikawa Endometrial CancerInternational Journal of Molecular Sciences · 2026
4. Molecular Basis of NPY Recognition and Ligand Selectivity at the Neuropeptide Y 5 ReceptorAngewandte Chemie · 2026
5. Molecular Basis of NPY Recognition and Ligand Selectivity at the Neuropeptide Y 5 ReceptorAngewandte Chemie International Edition · 2026
6. Sodium oligomannate remodels gut redox adaptation and promotes microbiota-derived indole-3-propionic acid production to alleviate Alzheimer’s diseaseGut · 2026
7. Multiple allosteric sites allow for synergistic enhancement of GPCR signalingScience Advances · 2026
8. Liver-Targeted DGAT2 siRNA Ameliorates Steatosis and Fibrosis in a High-Fat Diet–Induced MASH Mouse ModelJournal of drug targeting · 2026
9. Large Language Model‐Assisted Prediction and Virtual Screening of Near‐Infrared‐II Fluorescent MoleculesSmall · 2026
10. IRF2BP2-FOSL2 interaction regulates SOX9-mediated cartilage regeneration in osteoarthritis modelsJournal of Clinical Investigation · 2026
11. Lipid-organized tetramerization of PLPP1 defines the molecular basis of spatial lipid phosphate signalingNature Communications · 2026
12. FtmOx1-catalyzed diverse C(sp3)-H oxyfunctionalization enables versatile late-stage diversification of phenethylamines and tetrahydroisoquinolinesNature Communications · 2026
13. EP300 inhibition alleviates acute-on-chronic liver failure through modulation of scar-associated macrophagesNature Communications · 2026
14. Neonatal overfeeding accelerates age-related sarcopenia and metabolic disorders through lifelong gut mucosa and microbiota programming in miceNature Communications · 2026
15. Evaluating generative models for structure-based drug discovery from de novo design to lead optimizationNature Communications · 2026
16. Photoinduced Copper‐Catalyzed 1,2‐Alkyl Azolation of 1,3‐Enynes with NHPI Esters and AzolesChinese Journal of Chemistry · 2026
17. Low‐dose antiangiogenic multikinase inhibitor AL3810 synergizes with PD‐1 blockade by reducing CSF1‐driven MHC‐II int tumour‐associated macrophages to optimize TIM‐3 + CD8 + T‐cell effector functionBritish Journal of Pharmacology · 2026
18. Sarbecoviruses Suppress Innate Immunity by Recruiting PPM1A to Modulate STAT2 and ORF9b PhosphorylationAdvanced Science · 2026
19. Substrate-Controlled Co-MHAT Catalyzed 1,4- and 1,2-Hydropyridination of 1,3-EnynesOrganic Letters · 2026
20. A Cathepsin B -Cleavable Self-Immolative Linker for the Delivery of Hydroxyl-Containing Payloads in Antibody–Drug ConjugatesBioconjugate Chemistry · 2026