Bone Therapeutics

Recent papers from Bone Therapeutics

1. FFAR2 activation induces IL-22-dependent intestinal immune responses to suppress CNS autoimmunityEMBO Molecular Medicine · 2026
2. Activation of Intestinal Type 3 Innate Lymphoid Cells and Regulatory T Cells Through Free Fatty Acid Receptor 2 Ameliorates Type 1 Diabetes in MiceDiabetes · 2026
3. Ferroptosis-armed dendritic cell vaccines for glioma immunotherapyNature Communications · 2026
4. PPARγ activation by leriglitazone counteracts neurodegeneration and neuroinflammation in a disease-relevant mouse model of COASY dysfunctionPharmacological Research · 2026
5. Optimization of METTL3 Inhibitors for the Treatment of Solid Tumors and AMLJournal of Medicinal Chemistry · 2026
6. Abstract 7062: EP102: Pharmacological inhibition of METTL3 is effective as a monotherapy and potentiates radiation therapy in pancreatic adenocarcinoma via DNA damage and stemness modulation.Cancer Research · 2026
7. Inhibition of A2AR alleviates adenosine-mediated suppression of plasma cell differentiationFrontiers in Immunology · 2025
8. ENT1 inhibition enhances weight control and metabolic health in diet-induced obesityBiomedicine & Pharmacotherapy · 2025
9. Single-cell mapping of alternative splicing linked to checkpoint immunotherapy responseNucleic Acids Research · 2025
10. Leriglitazone improves iron homeostasis and ferroptotic markers in frataxin-deficient dorsal root ganglia neuronsBiomedicine & Pharmacotherapy · 2025
11. A2AR-mediated inhibition of B cell maturation: a novel mechanism of immune suppression in cancer2025
12. Inhibition of ENT1 relieves intracellular adenosine-mediated T cell suppression in cancerNature Immunology · 2025
13. Amelioration of Central Nervous System Autoimmunity Through FFAR2 Agonism Is Associated With Changes in Gut MicrobiotaBrain and Behavior · 2025
14. Discovery, Optimization, and Preclinical Pharmacology of EP652, a METTL3 Inhibitor with Efficacy in Liquid and Solid Tumor ModelsJournal of Medicinal Chemistry · 2025
15. Discovery of UCB9386: A Potent, Selective, and Brain-Penetrant Nuak1 Inhibitor Suitable for In Vivo Pharmacological StudiesJournal of Medicinal Chemistry · 2024
16. Structure elucidation of a human melanocortin-4 receptor specific orthosteric nanobody agonistNature Communications · 2024
17. Cannabidiol ameliorates mitochondrial disease via PPARγ activation in preclinical modelsNature Communications · 2024
18. Feasibility of a fully endoscopic one-anastomosis gastric bypass procedure after endoscopic sleeve gastroplasty in pigsiGIE · 2024
19. Radiprodil, a selective GluN2B negative allosteric modulator, rescues audiogenic seizures in mice carrying the GluN2A(N615S) mutationBritish Journal of Pharmacology · 2024
20. Abstract 734: Inhibition of equilibrative nucleoside transporter 1 relieves intracellular adenosine-mediated immune suppressionCancer Research · 2024