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August 16, 2025Open Access

A2AR-mediated inhibition of B cell maturation: a novel mechanism of immune suppression in cancer

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Authors

PTPaola TieppoBone TherapeuticsHSHussein ShehadeBone TherapeuticsCMChiara MartinoliBone Therapeutics

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Overview

This research demonstrates A2AR's role in immune suppression by inhibiting B cell maturation in cancer, suggesting potential therapeutic avenues.

Key Points

  • A2AR significantly impairs B cell maturation into antibody-secreting cells (ASCs) in the tumor microenvironment, leading to immune suppression.
  • Plasma cells were found to be the most affected immune cells by adenosine, with A2AR inhibition restoring their function and numbers.
  • Analysis of tumor biopsies showed that ASCs increase in tertiary lymphoid structures post-treatment with A2AR antagonist inupadenant.
  • Overall, these findings indicate a B cell-intrinsic mechanism of immune suppression in cancer via A2AR modulation.

Cite This Study

Tieppo et al. (2025) studied this question.

synapsesocial.com/papers/68af4760ad7bf08b1ead450dhttps://doi.org/10.1101/2025.08.13.669666
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