Carmot Therapeutics (United States)

Recent papers from Carmot Therapeutics (United States)

1. An open‐label study on ulotaront's effects on insulin‐glucose regulation in schizophrenia patients with metabolic syndrome and prediabetes: Part IDiabetes Obesity and Metabolism · 2025
2. Biased agonism of GLP-1R and GIPR enhances glucose lowering and weight loss, with dual GLP-1R/GIPR biased agonism yielding greater efficacyCell Reports Medicine · 2025
3. The Goldilocks for chronic weight management—Balancing quantity with quality of weight lossDiabetes Obesity and Metabolism · 2025
4. The HER2-directed antibody-drug conjugate DHES0815A in advanced and/or metastatic breast cancer: preclinical characterization and phase 1 trial resultsNature Communications · 2024
5. Disruption of SUV39H1 -Mediated H3K9 Methylation Sustains CAR T-cell FunctionCancer Discovery · 2023
6. SUV39H1 Ablation Enhances Long-term CAR T Function in Solid TumorsCancer Discovery · 2023
7. Editorial: Mitochondrial Biology and Its Role in Metabolic DiseasesFrontiers in Endocrinology · 2022
8. Discovery of N-(1-Acryloylazetidin-3-yl)-2-(1H-indol-1-yl)acetamides as Covalent Inhibitors of KRASG12CACS Medicinal Chemistry Letters · 2019
9. Fragment-to-Lead Medicinal Chemistry Publications in 2017Journal of Medicinal Chemistry · 2018
10. Co(II) and Ni(II) binding of the Escherichia coli transcriptional repressor RcnR orders its N terminus, alters helix dynamics, and reduces DNA affinityJournal of Biological Chemistry · 2017
11. Fragment-to-Lead Medicinal Chemistry Publications in 2016Journal of Medicinal Chemistry · 2017
12. Fragment-to-Lead Medicinal Chemistry Publications in 2015Journal of Medicinal Chemistry · 2016
13. Design Principles for Fragment Libraries: Maximizing the Value of Learnings from Pharma Fragment-Based Drug Discovery (FBDD) Programs for Use in AcademiaJournal of Medicinal Chemistry · 2016
14. Learning from PAINful lessonsJournal of Medicinal Chemistry · 2015
15. Validity of Ligand Efficiency MetricsACS Medicinal Chemistry Letters · 2014
16. Learning from our mistakes: The ‘unknown knowns’ in fragment screeningBioorganic & Medicinal Chemistry Letters · 2013