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Starting with anecdotal reports there is now increasing evidence that chronic non-communicable diseases such as type 2 diabetes, obesity, cancer, and several neurodegenerative conditions may be interlinked by common pathobiological mechanisms. Mitochondria are prime candidates to modulate such intersecting processes because of their crucial role in energy homeostasis influencing nearly every tissue and organ of the body. Defects in mitochondrial metabolism can occur at all ages and produce a plethora of multiorgan symptoms, as illustrated through the research compiled for this Research Topic of Frontiers in Endocrinology.
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Schneider et al. (2022) studied this question.
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