Why the study?
Does pre-term delivery increase the maternal risk of subsequent ischaemic heart disease?
Population
750,350 women who delivered a live, singleton infant following their first pregnancy, restricted to women…
Comparison
Pre-term delivery (elective and spontaneous) vs Term delivery and comparison between elective vs…
Design
Cohort
Key result
Pre-term delivery was associated with an increased risk of total ischaemic heart disease events (HR 1.58; 95% CI 1.47-1.71), with a stronger association for elective versus spontaneous delivery.
Authors
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May warrant closer IHD surveillance after preterm delivery; leaves open causal mechanisms and need for prospective trials.
Cohort (n=750,350)
Does pre-term delivery increase the maternal risk of subsequent ischaemic heart disease?
Hazard Ratio: 1.58 (95% CI 1.47–1.71)
Elective pre-term delivery is associated with a higher maternal risk of subsequent ischaemic heart disease compared to spontaneous pre-term delivery, suggesting a shared underlying predisposition to placental dysfunction and IHD.
Hastie et al. (2011) conducted a cohort in Ischaemic heart disease (n=750,350). Pre-term delivery vs. Term delivery was evaluated on Total IHD events (fatal and non-fatal) (HR 1.58, 95% CI 1.47-1.71). Pre-term delivery was associated with an increased risk of total ischaemic heart disease events (HR 1.58; 95% CI 1.47-1.71), with a stronger association for elective versus spontaneous delivery.
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