Why the study?
Women who deliver preterm are at risk of cardiovascular disease, but the reason for this association remains unclear.
Does preterm delivery increase the risk of future maternal cardiovascular hospitalization in pregnant women?
Population
1 199 364 pregnant women in Quebec between 1989 and 2017
Comparison
Very and moderate preterm delivery vs term delivery
Design
Longitudinal cohort study
Follow-up
19 186 983 person-years
Key result
Very preterm delivery was associated with an increased risk of maternal cardiovascular hospitalization (HR 1.67; 95% CI, 1.56-1.79) compared with term delivery.
Authors
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Very preterm delivery may warrant enhanced long-term maternal CV surveillance; extends prior associations but leaves causality and interventions open.
Cohort (n=1,199,364)
Does preterm delivery increase the risk of future maternal cardiovascular hospitalization in pregnant women?
Hazard Ratio: 1.67 (95% CI 1.56–1.79)
Absolute Event Rate: 43.7% vs 26.2%
Preterm delivery is associated with an increased risk of future maternal cardiovascular hospitalization, with vascular disorders during pregnancy (especially preeclampsia) explaining up to a quarter of this association.
Auger et al. (2020) conducted a cohort in Preterm delivery (n=1,199,364). Preterm delivery (very and moderate) vs. Term delivery was evaluated on Maternal cardiovascular hospitalization (HR 1.67, 95% CI 1.56-1.79). Very preterm delivery was associated with an increased risk of maternal cardiovascular hospitalization (HR 1.67; 95% CI, 1.56-1.79) compared with term delivery.