Key result
Preeclampsia history linked to ~190% greater long-term hypertension risk alongside other major cardiovascular events.
Why the study?
Preeclampsia causes systemic vascular injury and multi-organ damage that can persist after pregnancy, prompting examination of its long-term cardiovascular risks.
Does a history of preeclampsia increase the long-term risk of cardiovascular morbidity and mortality in women?
Population
1 014 749 women with 2 050 970 deliveries
Comparison
History of preeclampsia vs controls
Design
Nationwide registry-based case-cohort study
Follow-up
Median 18.1 years for preeclampsia group and 21.1 years for controls
Authors
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May warrant closer long-term CV surveillance after preeclampsia; leaves open causality and benefit of targeted prevention.
Cohort (n=1,014,749)
Yes
Does a history of preeclampsia increase the long-term risk of cardiovascular morbidity and mortality in women?
A history of preeclampsia is associated with a significantly increased long-term risk of cardiovascular morbidity, including a 2- to 3-fold increased risk of cardiovascular mortality.
Kantomaa et al. (2026) conducted a cohort in Preeclampsia (n=1,014,749). History of preeclampsia vs. Controls (women without preeclampsia) was evaluated on Hypertension, ischemic heart disease, stroke, pulmonary heart disease, heart failure, type 2 diabetes, thromboembolism and related mortality. A history of preeclampsia significantly increased the long-term risk of cardiovascular outcomes, including hypertension (HR 2.90), ischemic heart disease (HR 2.05), and stroke (HR 2.25).
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