Supplementary figure S15 from Tumor Cell–Intrinsic Decr2 Regulates Ferroptosis and Immunotherapy Efficacy

Key Points

• MAIN FINDING: Decr2 does not influence glutathione levels, which are crucial in ferroptosis.
• KEY EVIDENCE: Measurements of reduced glutathione (GSH), oxidized glutathione (GSSG), and their ratio show no changes.
• APPROACH: Analysis involved assessing ferroptosis-related genes and glutathione metrics in a tumor context.
• SIGNIFICANCE: Understanding decr2's non-role in glutathione dynamics helps clarify mechanisms of immunotherapy efficacy.