Supplementary figure S15 from Tumor Cell–Intrinsic Decr2 Regulates Ferroptosis and Immunotherapy Efficacy

Shuyin Li; Jason W. Shapiro; Hardik Shah; Emily F. Higgs; Lishi Xie; Yaopeng Li; Yuanyuan Zha; Jonathan Trujillo; Alexandra Cabanov; Tyler A. Jones; Blake Flood; Ken Hatogai; Ruxandra Tonea; Justin Kline; Thomas F. Gajewski

doi:10.1158/2326-6066.29760112

August 1, 2025

Supplementary figure S15 from Tumor Cell–Intrinsic Decr2 Regulates Ferroptosis and Immunotherapy Efficacy

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Key Points

MAIN FINDING: Decr2 does not influence glutathione levels, which are crucial in ferroptosis.
APPROACH: Analysis involved assessing ferroptosis-related genes and glutathione metrics in a tumor context.
SIGNIFICANCE: Understanding decr2's non-role in glutathione dynamics helps clarify mechanisms of immunotherapy efficacy.

Implication

Supplementary figure reveals decr2 does not impact glutathione levels in ferroptosis, suggesting its limited role in immunotherapy outcomes.

Abstract

Supplementary Figure S15. Decr2 does not affect reduced glutathione (GSH), oxidized glutathione (GSSG), GSH/GSSG ratio, or expression of other ferroptosis genes.

Discussion

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Cite This Study

Li et al. (2025) studied this question.

synapsesocial.com/papers/689a0c72e6551bb0af8d0277 https://doi.org/10.1158/2326-6066.29760112

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Supplementary figure S15 from Tumor Cell–Intrinsic Decr2 Regulates Ferroptosis and Immunotherapy Efficacy

Key Points

Implication

Abstract

Discussion

Cite This Study

Supplementary figure S15 from Tumor Cell–Intrinsic Decr2 Regulates Ferroptosis and Immunotherapy Efficacy

Key Points

Implication

Abstract

Discussion

Cite This Study

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