Figure S15 from B7-H3 CAR T Cells Are Effective against Ependymomas but Limited by Tumor Size and Immune Response

Key Points

• Increased inhibitory marker expression in B7-H3 CAR T-cells highlights a significant immune response.
• The study shows limitations for these CAR T-cells against ependymomas due to tumor size and immune interactions.
• Findings were derived through analysis comparing B7-H3 and HER2 CAR T-cells under repeated stimulation.
• Research suggests potential therapeutic challenges for CAR T-cells in large tumors with strong immune responses.