Discussion article highlights immunopathological syndromes related to adaptive immunity in various diseases, indicating a need for unified definitions.
This article is a continuation of the two previous ones on immunopathological syndromes in the diagnosis of various diseases. Analysis of these syndromes allows for a deeper understanding of the pathogenetic mechanisms of disease development, which is critical for timely diagnosis and effective therapy. Immunopathological syndromes associated with adaptive immunity are considered. Systemic immunopathological reactions of the cellular and humoral links of immunity are determined. Syndromes characteristic of the cellular response of types 1, 2 and 3 are highlighted. Manifestations associated with immunosuppression disorders are separately determined. When assessing immunopathological syndromes of the humoral link of the immune system, their differentiation by the class of immunoglobulins A, M, E and four subclasses of immunoglobulins G is proposed. In this discussion article, we propose to unify the definitions of immunopathological syndromes associated with adaptive immunity in order to provide doctors with information on the conceptual basis for the development of immunopathological syndromes. We also want to try to unify the definition of immunopathological syndromes, the main tools for assessment, staging and therapy.
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Анисимова et al. (2025) studied this question.
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