Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
August 5, 2025Organic Letters

Formal α-Nucleophilic Addition to Electron-Deficient Alkenes by Photoredox and Copper Dual Catalysis

View Full Paper
Ask AI
Bookmark
Share

Authors

YXYuping XiongHunan University of Science and TechnologyZZZhiyi ZhouXi’an Jiaotong-Liverpool UniversityYZYahan ZhangZheJiang Institute For Food and Drug Control

Discussion

Loading...

Member takes

Implication

This approach demonstrates sulfonylation efficiency in electron-deficient alkenes, suggesting improved methods for complex molecule construction.

Key Points

  • MAIN FINDING: The study reveals a novel photoredox/copper dual catalytic system for α-nucleophilic addition to electron-deficient alkenes.
  • KEY EVIDENCE: The methodology allows for the successful synthesis of various sulfonyl-substituted lactone derivatives under mild conditions.
  • APPROACH: Utilized a SO2-insertion strategy, demonstrating wide substrate scope and good functional group compatibility.
  • SIGNIFICANCE: This advancement in difunctionalization techniques has practical implications for constructing complex molecules in organic synthesis.

Cite This Study

Xiong et al. (2025) studied this question.

synapsesocial.com/papers/689521e49f4f1c896c4282e8https://doi.org/10.1021/acs.orglett.5c02573
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Conversion of Carboxylic Acids to Sulfonamide Bioisosteres via Energy Transfer Photocatalysis2024 · 16 citations
  2. 2Access to chiral β-sulfonyl carbonyl compounds via photoinduced organocatalytic asymmetric radical sulfonylation with sulfur dioxide2022 · 67 citations
  3. 3Enantioselective Bromolactonization of Deactivated Olefinic Acids2018 · 39 citations
  4. 4N-Functionalized Pyridinium Salts: A New Chapter for Site-Selective Pyridine C–H Functionalization via Radical-Based Processes under Visible Light Irradiation2022 · 154 citations
  5. 5Recent advances in copper-catalysed radical-involved asymmetric 1,2-difunctionalization of alkenes2019 · 783 citations